Building epithelial architecture: insights from three-dimensional culture models
LE O'Brien, MMP Zegers, KE Mostov - Nature reviews Molecular cell …, 2002 - nature.com
LE O'Brien, MMP Zegers, KE Mostov
Nature reviews Molecular cell biology, 2002•nature.comHow do individual cells organize into multicellular tissues? Here, we propose that the
morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic
differentiation programme that drives formation of a lumen-enclosing monolayer, and a
growth factor-induced, transient de-differentiation that allows this monolayer to be
remodelled.
morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic
differentiation programme that drives formation of a lumen-enclosing monolayer, and a
growth factor-induced, transient de-differentiation that allows this monolayer to be
remodelled.
Abstract
How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.
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