Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans
LS Metelitsa - Clinical Immunology, 2011 - Elsevier
Vα24-invariant natural killer T cells (NKTs) are strictly CD1d-restricted, and CD1d
expression has been found in several types of leukemia and lymphoma as well as in brain
tumors suggesting that these malignancies could be targeted for direct NKT-cell cytotoxicity.
Several studies have revealed strong positive associations between the numbers of tumor-
infiltrating or circulating NKTs with improved disease outcome in patients with diverse types
of CD1d-negative solid tumors. The mechanism by which NKTs mediate anti-tumor activity …
expression has been found in several types of leukemia and lymphoma as well as in brain
tumors suggesting that these malignancies could be targeted for direct NKT-cell cytotoxicity.
Several studies have revealed strong positive associations between the numbers of tumor-
infiltrating or circulating NKTs with improved disease outcome in patients with diverse types
of CD1d-negative solid tumors. The mechanism by which NKTs mediate anti-tumor activity …
