Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis.
FY Liew, C Parkinson, S Millott, A Severn, M Carrier - Immunology, 1990 - ncbi.nlm.nih.gov
FY Liew, C Parkinson, S Millott, A Severn, M Carrier
Immunology, 1990•ncbi.nlm.nih.govGenetically resistant CBA mice developed significantly larger lesions to Leishmania major
infection when they were injected with rabbit anti-tumour necrosis factor (TNF)-specific
antibodies compared to control mice injected with normal rabbit immunoglobulin. BALB/c
mice recovered from a previous infection following prophylactic sublethal irradiation also
developed exacerbated lesions when treated with the anti-TNF antibody. Injection of TNF
into the lesion of infected CBA mice significantly reduced the lesion development …
infection when they were injected with rabbit anti-tumour necrosis factor (TNF)-specific
antibodies compared to control mice injected with normal rabbit immunoglobulin. BALB/c
mice recovered from a previous infection following prophylactic sublethal irradiation also
developed exacerbated lesions when treated with the anti-TNF antibody. Injection of TNF
into the lesion of infected CBA mice significantly reduced the lesion development …
Abstract
Genetically resistant CBA mice developed significantly larger lesions to Leishmania major infection when they were injected with rabbit anti-tumour necrosis factor (TNF)-specific antibodies compared to control mice injected with normal rabbit immunoglobulin. BALB/c mice recovered from a previous infection following prophylactic sublethal irradiation also developed exacerbated lesions when treated with the anti-TNF antibody. Injection of TNF into the lesion of infected CBA mice significantly reduced the lesion development. Furthermore, TNF activates macrophages to kill Leishmania in vitro. These data demonstrate that TNF plays an important role in mediating host-protection against cutaneous leishmaniasis.
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