[HTML][HTML] TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation
One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the
acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-
induced apoptosis. Enhanced cell death in TRADD−/− MEFs is associated with defective NF-
κB activation, indicating that the pro-survival function of TRADD in TRAIL signaling is
mediated at least in part via NF-κB activation. Moreover, siRNA knock-down of TRADD in
cancer cells sensitizes them to TRAIL-induced apoptosis. Thus, TRADD has a survival role …
acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-
induced apoptosis. Enhanced cell death in TRADD−/− MEFs is associated with defective NF-
κB activation, indicating that the pro-survival function of TRADD in TRAIL signaling is
mediated at least in part via NF-κB activation. Moreover, siRNA knock-down of TRADD in
cancer cells sensitizes them to TRAIL-induced apoptosis. Thus, TRADD has a survival role …
One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis. Enhanced cell death in TRADD−/− MEFs is associated with defective NF-κB activation, indicating that the pro-survival function of TRADD in TRAIL signaling is mediated at least in part via NF-κB activation. Moreover, siRNA knock-down of TRADD in cancer cells sensitizes them to TRAIL-induced apoptosis. Thus, TRADD has a survival role in TRAIL signaling and may be one potential target for overcoming TRAIL resistance in cancer therapy. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: TRAILphysically interacts with FADD and RIP1 by pull down(View interaction)
Elsevier
