[HTML][HTML] Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer
E Coutanceau, P Legras, L Marsollier, G Reysset… - Microbes and …, 2006 - Elsevier
Buruli ulcer, a disease caused by Mycobacterium ulcerans, is emerging as an increasingly
important cause of morbidity throughout the world, for which surgery is the only efficient
treatment to date. The aim of this work was to identify potential vaccine candidates in an
experimental model of mouse infection. In BALB/c mice infected with M. ulcerans
subcutaneously, Hsp65 appeared to be an immunodominant antigen eliciting both humoral
and cellular responses. However, vaccination of mice with a DNA vector encoding …
important cause of morbidity throughout the world, for which surgery is the only efficient
treatment to date. The aim of this work was to identify potential vaccine candidates in an
experimental model of mouse infection. In BALB/c mice infected with M. ulcerans
subcutaneously, Hsp65 appeared to be an immunodominant antigen eliciting both humoral
and cellular responses. However, vaccination of mice with a DNA vector encoding …
