BACE1 suppression by RNA interference in primary cortical neurons
Extracellular deposition of amyloid-β (Aβ) aggregates in the brain represents one of the
histopathological hallmarks of Alzheimer's disease (AD). Aβ peptides are generated from
proteolysis of the amyloid precursor proteins (APPs) by β-and γ-secretases. β-Secretase
(BACE1) is a type I integral membrane glycoprotein that can cleave APP first to generate C-
terminal 99-or 89-amino acid membrane-bound fragments containing the N terminus of Aβ
peptides (βCTF). As BACE1 cleavage is an essential step for Aβ generation, it is proposed …
histopathological hallmarks of Alzheimer's disease (AD). Aβ peptides are generated from
proteolysis of the amyloid precursor proteins (APPs) by β-and γ-secretases. β-Secretase
(BACE1) is a type I integral membrane glycoprotein that can cleave APP first to generate C-
terminal 99-or 89-amino acid membrane-bound fragments containing the N terminus of Aβ
peptides (βCTF). As BACE1 cleavage is an essential step for Aβ generation, it is proposed …
