Focal adhesion kinase: an integrin-linked protein tyrosine kinase
MD Schaller, JT Parsons - Trends in cell biology, 1993 - Elsevier
MD Schaller, JT Parsons
Trends in cell biology, 1993•ElsevierRecent evidence has shown that binding of integrins to components of the extracellular
matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and
activation of intracellular signalling pathways. Here we review the evidence that protein
tyrosine kinases, including focal-adhesion-associated kinases, play a central role in the
generation of some of these molecular signals.
matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and
activation of intracellular signalling pathways. Here we review the evidence that protein
tyrosine kinases, including focal-adhesion-associated kinases, play a central role in the
generation of some of these molecular signals.
Abstract
Recent evidence has shown that binding of integrins to components of the extracellular matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and activation of intracellular signalling pathways. Here we review the evidence that protein tyrosine kinases, including focal-adhesion-associated kinases, play a central role in the generation of some of these molecular signals.
Elsevier
