CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis—an intravital microscopy study
AC Dos Santos, MM Barsante, RME Arantes… - Journal of …, 2005 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) models multiple sclerosis (MS) and is
characterized by marked mononuclear cell influx in the brain. Several studies have
demonstrated a role for chemokines during EAE. It remains to be determined whether these
mediators modulate EAE primarily by mediating leukocyte influx into the CNS or by
modifying lymphocyte activation and/or trafficking into lymphoid organs. After induction of
EAE with MOG35–55, leukocyte recruitment peaked on day 14 and correlated with symptom …
characterized by marked mononuclear cell influx in the brain. Several studies have
demonstrated a role for chemokines during EAE. It remains to be determined whether these
mediators modulate EAE primarily by mediating leukocyte influx into the CNS or by
modifying lymphocyte activation and/or trafficking into lymphoid organs. After induction of
EAE with MOG35–55, leukocyte recruitment peaked on day 14 and correlated with symptom …
