[HTML][HTML] Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis
The lysosomal cysteine protease cathepsin B is thought to play a central role in
intrapancreatic trypsinogen activation and the onset of experimental pancreatitis. Recent in
vitro studies have suggested that this mechanism might be of pathophysiological relevance
in hereditary pancreatitis, a human inborn disorder associated with mutations in the cationic
trypsinogen gene. In the present study evidence is presented that cathepsin B is abundantly
present in the secretory compartment of the human exocrine pancreas, as judged by …
intrapancreatic trypsinogen activation and the onset of experimental pancreatitis. Recent in
vitro studies have suggested that this mechanism might be of pathophysiological relevance
in hereditary pancreatitis, a human inborn disorder associated with mutations in the cationic
trypsinogen gene. In the present study evidence is presented that cathepsin B is abundantly
present in the secretory compartment of the human exocrine pancreas, as judged by …
