[HTML][HTML] Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I
K Ohtani, R Iwanaga, M Arai, Y Huang… - Journal of Biological …, 2000 - ASBMB
The transactivator protein Tax of human T-cell leukemia virus type I plays an important role
in the development of adult T-cell leukemia probably through modulation of growth
regulatory molecules including p16 INK4a. The molecular mechanism of leukemogenesis
induced by Tax has yet to be elucidated. We analyzed Tax function in the cell cycle using an
interleukin-2 (IL-2)-dependent human T-cell line (Kit 225) that can undergo cell cycle arrest
at G 0/G 1 phase by deprivation of IL-2. Tax activated endogenous E2F activity in IL-2 …
in the development of adult T-cell leukemia probably through modulation of growth
regulatory molecules including p16 INK4a. The molecular mechanism of leukemogenesis
induced by Tax has yet to be elucidated. We analyzed Tax function in the cell cycle using an
interleukin-2 (IL-2)-dependent human T-cell line (Kit 225) that can undergo cell cycle arrest
at G 0/G 1 phase by deprivation of IL-2. Tax activated endogenous E2F activity in IL-2 …
