Clonal expansion of infected cells: a way of life for HTLV-I
E Wattel, M Cavrois, A Gessain… - JAIDS Journal of …, 1996 - journals.lww.com
E Wattel, M Cavrois, A Gessain, S Wain-Hobson
JAIDS Journal of Acquired Immune Deficiency Syndromes, 1996•journals.lww.comHuman T-cell lymphotropic virus type I (HTLV-I) is characterized by a remarkable genetic
stability and high proviral loads in the absence of malignant disease. This results from the
effect of tax on cell cycling. The virus replicates essentially in concert with the cell, that is, via
mitosis, which can be shown by polymerase chain reaction amplification of the HTLV-I
integration sites. This is true of all stages of HTLV-I infection and accompanies adult T-cell
leukemia/lymphoma. The very low viremia results from its genetic organization.
stability and high proviral loads in the absence of malignant disease. This results from the
effect of tax on cell cycling. The virus replicates essentially in concert with the cell, that is, via
mitosis, which can be shown by polymerase chain reaction amplification of the HTLV-I
integration sites. This is true of all stages of HTLV-I infection and accompanies adult T-cell
leukemia/lymphoma. The very low viremia results from its genetic organization.
Abstract
Human T-cell lymphotropic virus type I (HTLV-I) is characterized by a remarkable genetic stability and high proviral loads in the absence of malignant disease. This results from the effect of tax on cell cycling. The virus replicates essentially in concert with the cell, that is, via mitosis, which can be shown by polymerase chain reaction amplification of the HTLV-I integration sites. This is true of all stages of HTLV-I infection and accompanies adult T-cell leukemia/lymphoma. The very low viremia results from its genetic organization.
Lippincott Williams & Wilkins