Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system
After an injury to the central nervous system (CNS), activated microglia have been shown to
contribute to the ongoing destructive processes leading to secondary neuronal
degeneration. They can, however, also express neuroprotective activity. Studies from our
laboratory point to the existence of a physiological T cell-mediated neuroprotective
mechanism (adaptive immunity) that is amenable to boosting. We postulate that the
beneficial or destructive outcome of the local microglial (innate) response is determined by a …
contribute to the ongoing destructive processes leading to secondary neuronal
degeneration. They can, however, also express neuroprotective activity. Studies from our
laboratory point to the existence of a physiological T cell-mediated neuroprotective
mechanism (adaptive immunity) that is amenable to boosting. We postulate that the
beneficial or destructive outcome of the local microglial (innate) response is determined by a …
