Dexamethasone treatment of congenital adrenal hyperplasia in utero: an experimental therapy of unproven safety
WL Miller - The Journal of urology, 1999 - Elsevier
Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency is a
common cause of genital virilization in female infants resulting from inappropriate fetal
adrenal androgen secretion. Some investigators have advocated treating pregnant women
who are at risk for carrying a CAH fetus with dexamethasone to suppress fetal adrenal
androgen synthesis. Experience to date shows that this treatment can be effective in
ameliorating the genital virilization in female fetuses. However, the doses used are …
common cause of genital virilization in female infants resulting from inappropriate fetal
adrenal androgen secretion. Some investigators have advocated treating pregnant women
who are at risk for carrying a CAH fetus with dexamethasone to suppress fetal adrenal
androgen synthesis. Experience to date shows that this treatment can be effective in
ameliorating the genital virilization in female fetuses. However, the doses used are …
