Bone morphogenetic proteins and bone morphogenetic protein gene therapy in neurological surgery: a review
GA Helm, TD Alden, JP Sheehan, D Kallmes - Neurosurgery, 2000 - journals.lww.com
OBJECTIVE: To review the uses of bone morphogenetic proteins (BMPs) and BMP gene
therapy for the treatment of neurosurgical disorders. METHODS: Literature review.
RESULTS: BMPs are members of the transforming growth factor β superfamily, and they
play an important role in the growth and development of numerous tissues, including bone,
brain, and spinal cord. Although the majority of previous studies have focused on the
regulatory functions of BMPs in the normal growth and differentiation of the skeletal system …
therapy for the treatment of neurosurgical disorders. METHODS: Literature review.
RESULTS: BMPs are members of the transforming growth factor β superfamily, and they
play an important role in the growth and development of numerous tissues, including bone,
brain, and spinal cord. Although the majority of previous studies have focused on the
regulatory functions of BMPs in the normal growth and differentiation of the skeletal system …
