Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
L Qiu, C Joazeiro, N Fang, HY Wang, C Elly… - Journal of Biological …, 2000 - ASBMB
Genetic studies identified Itch, which is a homologous to the E6-associated protein carboxyl
terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti
lethal mice or Itchy mice. Itch-deficiency results in abnormal immune responses and
constant itching in the skin. Here, Itch was shown to associate with Notch, a protein involved
in cell fate decision in many mammalian cell types, including cells in the immune system.
Itch binds to the N-terminal portion of the Notch intracellular domain via its WW domains and …
terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti
lethal mice or Itchy mice. Itch-deficiency results in abnormal immune responses and
constant itching in the skin. Here, Itch was shown to associate with Notch, a protein involved
in cell fate decision in many mammalian cell types, including cells in the immune system.
Itch binds to the N-terminal portion of the Notch intracellular domain via its WW domains and …
