ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation
RJ Aiello, D Brees, OL Francone - Arteriosclerosis, thrombosis, and …, 2003 - Am Heart Assoc
RJ Aiello, D Brees, OL Francone
Arteriosclerosis, thrombosis, and vascular biology, 2003•Am Heart AssocStudies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in
demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL
metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype
observed in human Tangier disease, including substantial reductions in both apolipoprotein
B and apolipoprotein AI with confounding affects on atherosclerosis.
demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL
metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype
observed in human Tangier disease, including substantial reductions in both apolipoprotein
B and apolipoprotein AI with confounding affects on atherosclerosis.
Studies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
Am Heart Assoc
