[HTML][HTML] LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
S Murthy, E Born, SN Mathur, FJ Field - Journal of lipid research, 2002 - ASBMB
Regulation of gene expression of ATP-binding cassette transporter (ABC) A1 and ABCG1 by
liver X receptor/retinoid X receptor (LXR/RXR) ligands was investigated in the human
intestinal cell line CaCo-2. Neither the RXR ligand, 9-cis retinoic acid, nor the natural LXR
ligand 22-hydroxycholesterol alone altered ABCA1 mRNA levels. When added together,
ABCA1 and ABCG1 mRNA levels were increased 3-and 7-fold, respectively. T0901317, a
synthetic non-sterol LXR agonist, increased ABCA1 and ABCG1 gene expression 11-and 6 …
liver X receptor/retinoid X receptor (LXR/RXR) ligands was investigated in the human
intestinal cell line CaCo-2. Neither the RXR ligand, 9-cis retinoic acid, nor the natural LXR
ligand 22-hydroxycholesterol alone altered ABCA1 mRNA levels. When added together,
ABCA1 and ABCG1 mRNA levels were increased 3-and 7-fold, respectively. T0901317, a
synthetic non-sterol LXR agonist, increased ABCA1 and ABCG1 gene expression 11-and 6 …
