[HTML][HTML] ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens
JD Mulligan, MT Flowers, A Tebon, JJ Bitgood… - Journal of Biological …, 2003 - ASBMB
The ATP-binding cassette transporter A1 (ABCA1) participates in the efflux of cholesterol
from cells. It remains unclear whether ABCA1 functions to efflux cholesterol across the
basolateral or apical membrane of the intestine. We used a chicken model of ABCA1
dysfunction, the Wisconsin hypoalpha mutant (WHAM) chicken, to address this issue. After
an oral gavage of radioactive cholesterol, the percentage appearing in the bloodstream was
reduced by 79% in the WHAM chicken along with a 97% reduction in the amount of tracer in …
from cells. It remains unclear whether ABCA1 functions to efflux cholesterol across the
basolateral or apical membrane of the intestine. We used a chicken model of ABCA1
dysfunction, the Wisconsin hypoalpha mutant (WHAM) chicken, to address this issue. After
an oral gavage of radioactive cholesterol, the percentage appearing in the bloodstream was
reduced by 79% in the WHAM chicken along with a 97% reduction in the amount of tracer in …
