[HTML][HTML] The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm
EE Morrisey, S Musco, MYZ Chen, MM Lu… - Journal of Biological …, 2000 - ASBMB
Gene targeting studies have demonstrated that the zinc finger transcription factor GATA-6
lies upstream in a transcriptional cascade that controls differentiation of the visceral
endoderm. To understand the function of GATA-6 in the visceral endoderm and to identify
genes regulated by GATA-6 in this tissue, subtractive hybridization was performed using
template cDNAs derived from differentiated wild-type embryonic stem (ES) cells and GATA-
6−/− ES cells, respectively. These analyses revealed that the gene encoding Dab2, a …
lies upstream in a transcriptional cascade that controls differentiation of the visceral
endoderm. To understand the function of GATA-6 in the visceral endoderm and to identify
genes regulated by GATA-6 in this tissue, subtractive hybridization was performed using
template cDNAs derived from differentiated wild-type embryonic stem (ES) cells and GATA-
6−/− ES cells, respectively. These analyses revealed that the gene encoding Dab2, a …
