Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis
AM Di Bisceglie, P Osmack, EM Brunt - Journal of Laboratory and Clinical …, 2005 - Elsevier
Hepatocellular carcinoma (HCC) is common worldwide and growing in importance in the
West. HCC often occurs against a background of liver disease, tends to present at an
advanced stage, and has a poor prognosis, suggesting that it is an ideal target for
chemoprevention. We sought to identify in an animal model chemopreventive agents for
HCC that might be tested in human subjects. To this end, we induced liver tumors by
injecting ethyl-nitrosourea in 6-week-old male B6C3F1 mice. Two chemopreventive agents …
West. HCC often occurs against a background of liver disease, tends to present at an
advanced stage, and has a poor prognosis, suggesting that it is an ideal target for
chemoprevention. We sought to identify in an animal model chemopreventive agents for
HCC that might be tested in human subjects. To this end, we induced liver tumors by
injecting ethyl-nitrosourea in 6-week-old male B6C3F1 mice. Two chemopreventive agents …
