Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new
SS Hecht - Carcinogenesis, 2005 - academic.oup.com
SS Hecht
Carcinogenesis, 2005•academic.oup.comA new study demonstrates that lifetime whole-body exposure of B6C3F 1 mice to high doses
of cigarette smoke robustly increases lung cancer incidence compared with sham exposed
animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on
lung cancer in an animal model. This commentary attempts to put the new results in
perspective with the existing literature on cigarette smoke inhalation studies in animals and
discusses strengths, limitations and possible applications of available models.
of cigarette smoke robustly increases lung cancer incidence compared with sham exposed
animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on
lung cancer in an animal model. This commentary attempts to put the new results in
perspective with the existing literature on cigarette smoke inhalation studies in animals and
discusses strengths, limitations and possible applications of available models.
Abstract
A new study demonstrates that lifetime whole-body exposure of B6C3F 1 mice to high doses of cigarette smoke robustly increases lung cancer incidence compared with sham exposed animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on lung cancer in an animal model. This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations and possible applications of available models.
Oxford University Press