Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats: effect of sodium and salt restriction.
V Vallon, LM Wead, RC Blantz - Journal of the American Society of …, 1995 - journals.lww.com
Six weeks after the onset of insulin-treated streptozotocin diabetes (STZ) in Munich-Wistar
rats, the effect of a low-sodium (LNa) and a low-salt (LNaCl) diet on renal function and on
plasma and kidney tissue angiotensin II (AIIp, AIIk) was tested. Clearance experiments were
performed in anesthetized rats 7 days after starting on LNa or LNaCl. On a control diet, STZ
exhibited an increase in GFR, RBF, and kidney weight (KW) and a reduction in renal
vascular resistance (RVR) and AIIk, but no change in AIIp, compared with nondiabetic …
rats, the effect of a low-sodium (LNa) and a low-salt (LNaCl) diet on renal function and on
plasma and kidney tissue angiotensin II (AIIp, AIIk) was tested. Clearance experiments were
performed in anesthetized rats 7 days after starting on LNa or LNaCl. On a control diet, STZ
exhibited an increase in GFR, RBF, and kidney weight (KW) and a reduction in renal
vascular resistance (RVR) and AIIk, but no change in AIIp, compared with nondiabetic …
