Feedback control of glomerular vascular tone in neuronal nitric oxide synthase knockout mice
V Vallon, T Traynor, L Barajas, YG Huang… - Journal of the …, 2001 - journals.lww.com
For further elucidation of the role of neuronal nitric oxide synthase (nNOS) in macula densa
(MD) cells, experiments were performed in anesthetized nNOS knockout mice (nNOS-/-). At
comparable levels of arterial BP, renal blood flow was not significantly different between
nNOS+/+ and nNOS-/-(1.7±0.2 versus 1.4±0.1 ml/min), and autoregulation of renal blood
flow was maintained to a pressure level of approximately 85 mmHg in both groups of mice
(n= 6 in each group). The fall in proximal tubular stop-flow pressure in response to an …
(MD) cells, experiments were performed in anesthetized nNOS knockout mice (nNOS-/-). At
comparable levels of arterial BP, renal blood flow was not significantly different between
nNOS+/+ and nNOS-/-(1.7±0.2 versus 1.4±0.1 ml/min), and autoregulation of renal blood
flow was maintained to a pressure level of approximately 85 mmHg in both groups of mice
(n= 6 in each group). The fall in proximal tubular stop-flow pressure in response to an …
