Salt-sensitivity of proximal reabsorption alters macula densa salt and explains the paradoxical effect of dietary salt on glomerular filtration rate in diabetes mellitus
V Vallon, DY Huang, A Deng, K Richter… - Journal of the …, 2002 - journals.lww.com
GFR varies inversely with dietary NaCl in patients with early type I diabetes and in
streptozotocin (STZ)-diabetic rats. To explain this paradox within the laws of physiology, it
was hypothesized that it results from heightened sensitivity of the diabetic proximal tubule to
dietary salt because changes in proximal reabsorption (Jprox) elicit reciprocal adjustments
in GFR through the normal actions of tubuloglomerular feedback (TGF). Micropuncture was
done in rats after 5 wk of moderately hyperglycemic STZ-diabetes and 1 wk of different NaCl …
streptozotocin (STZ)-diabetic rats. To explain this paradox within the laws of physiology, it
was hypothesized that it results from heightened sensitivity of the diabetic proximal tubule to
dietary salt because changes in proximal reabsorption (Jprox) elicit reciprocal adjustments
in GFR through the normal actions of tubuloglomerular feedback (TGF). Micropuncture was
done in rats after 5 wk of moderately hyperglycemic STZ-diabetes and 1 wk of different NaCl …
