The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
G Lambert, MJA Amar, G Guo, HB Brewer… - Journal of Biological …, 2003 - ASBMB
To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol
homeostasis, we evaluated the major pathways of cholesterol metabolism in theFXR-
deficient (−/−) mouse model. Compared with wild-type, FXR (−/−) mice have increased
plasma high density lipoprotein (HDL) cholesterol and a markedly reduced rate of plasma
HDL cholesterol ester clearance. Concomitantly, FXR (−/−) mice exhibit reduced expression
of hepatic genes involved in reverse cholesterol transport, most notably, that for scavenger …
homeostasis, we evaluated the major pathways of cholesterol metabolism in theFXR-
deficient (−/−) mouse model. Compared with wild-type, FXR (−/−) mice have increased
plasma high density lipoprotein (HDL) cholesterol and a markedly reduced rate of plasma
HDL cholesterol ester clearance. Concomitantly, FXR (−/−) mice exhibit reduced expression
of hepatic genes involved in reverse cholesterol transport, most notably, that for scavenger …
