Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Eα-transgenic mice
G Zhu, DB Flies, K Tamada, Y Sun… - The Journal of …, 2001 - journals.aai.org
The Journal of Immunology, 2001•journals.aai.org
Abstract Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively
regulate cell-mediated and humoral immune responses. We have prepared transgenic
mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Eα promoter.
The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of
B220+ B cells accompanied with low levels of circulating IgG and defective humoral
responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide …
regulate cell-mediated and humoral immune responses. We have prepared transgenic
mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Eα promoter.
The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of
B220+ B cells accompanied with low levels of circulating IgG and defective humoral
responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide …
Abstract
Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Eα promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220+ B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.
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