[HTML][HTML] Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering
P Mittaud, PA Marangi, S Erb-Vögtli… - Journal of Biological …, 2001 - ASBMB
During neuromuscular synaptogenesis, neurally released agrin induces aggregation and
tyrosine phosphorylation of acetylcholine receptors (AChRs) by acting through both the
receptor tyrosine kinase MuSK (muscle-specific kinase) and the AChR-associated protein,
rapsyn. To elucidate this signaling mechanism, we examined tyrosine phosphorylation of
AChR-associated proteins, particularly addressing whether agrin activates Src family
kinases bound to the AChR. In C2 myotubes, agrin induced tyrosine phosphorylation of …
tyrosine phosphorylation of acetylcholine receptors (AChRs) by acting through both the
receptor tyrosine kinase MuSK (muscle-specific kinase) and the AChR-associated protein,
rapsyn. To elucidate this signaling mechanism, we examined tyrosine phosphorylation of
AChR-associated proteins, particularly addressing whether agrin activates Src family
kinases bound to the AChR. In C2 myotubes, agrin induced tyrosine phosphorylation of …
